Episode 1 - The Search

After an elderly couple inadvertently help a murderous bank robber slip through a police road block, a restaurant manager spots the fugitive who uses the old folks to keep from getting caught.

Episode 2 - Kidnap Copter

Jerry Watts is the son of a millionaire and he's just been kidnapped and taken to an old shack high in the mountains. After a tip from a game warden brings the Highway Patrol, Jerry tries to escape to the officers, only to fall into a canyon severely injuring himself. The only way out is straight up.

Episode 3 - Trailer Story

Steve Talbot is a jewel thief who likes nice automobiles, and the Highway Patrol knows this. So Talbot flees capture after a job in an old junker. This gets him past the roadblocks but he soon is stranded on the side of the road. He hijacks a newly married couple pulling a trailer and Dan passes the trio through, not wanting harm to come to the civilians. But in passing the blockade, they unknowingly pick up a new rider.

Episode 4 - Fisherman's Luck

A car that was involved in an accident is stolen and later found again, and just happens to match the description of one used in a bank holdup. Putting two and two together, Dan speculates that this was the getaway car and it's occupants must have escaped on foot, which is near a posh resort.

Episode 5 - Magazine Writer

Reporter Sam Dalquist has gone missing. Dan has been looking for him because a two bit hood was found dead after getting a traffic citation driving Dalquist's car. The only lead Mathews has is that Dalquist was working on an exposé about a hood named Matlock and that may be where the writer will be found...dead or alive.

Episode 6 - Typhoid Carrier

Hank Dooley's daughter has just died from typhoid fever, and Dooley is now searching for his farm hand Len Frazier who is the one who infected her, complete with rifle in hand.

Episode 7 - Hot Rod

Dan enlists the help of the leader of a local hot rod car club to assist in finding two robbers who use a souped-up car to get away from the Highway Patrol after each job.

Episode 8 - Hot Cargo

Several criminals conspire to stage highway accidents prompting truck drivers to stop and help victims only to be assaulted and have their cargoes stolen. After discovering the hijackers are being tipped off by the owner of a roadside diner favored by truckers, Chief Mathews creates a ruse to force the crime ring into action with the hopes of capturing them.

Episode 9 - Oil Lease

An Army bazooka is stolen by two men who use it to capture the payroll from an oil drilling company.

Episode 10 - Ex Con

The life of an ex-con is never easy, especially when cellmates show up expecting favors. Al Baldwin is a reformed criminal but suddenly has unexpected guests who hide out at his house while plotting their next crime. When that holdup goes bad, the cons hold Al's wife hostage until Dan and the Highway Patrol come to the rescue.

Episode 11 - Motel Robbery

Episode 12 - Stolen Car Ring

Episode 13 - Escaped Mental Patient

Episode 14 - Armored Car

Episode 15 - Migrant Workers

Episode 16 - Ranch Copter

A woman suspects her husband is trying to kill her. Iris: Virginia Dale. George: Douglas Henderson. Mathews: Broderick Crawford. Ted: Robert Cavendish.

Episode 17 - Amnesia

Episode 18 - Statute of Limitations

Mathews tries to prove the guilt of three holdup men---before the statute of limitations runs out. Mathews: Broderick Crawford. Eddie: Bing Russell. Wyatt: Mike Regan.

Episode 19 - Resident Officer

Episode 20 - Psycho

Episode 21 - Counterfeit

Mathews and the Highway Patrol investigate a rash of forged payroll-check cashings affecting merchants in and around Los Angeles.

Episode 22 - Suspected Cop

Episode 23 - Trojan Horse

Episode 24 - Female Hitchhiker

Episode 25 - Nitro

Episode 26 - Motorcycle B

Episode 27 - Officer's Wife

Episode 28 - Stripped Cars

Two brothers hijack a new-car carrier, planning to sell the cars to get cash to purchase a farm. When the driver dies from injuries sustained in the hijacking, they make a panic-stricken attempt to dispose of the evidence.

Episode 29 - Convict's Wife

Episode 30 - Reformation

An ex-con wants to return money stolen in an armed robbery, but his erstwhile partner has other ideas.

Episode 31 - Stolen Plane Copter

Two convicts steal an airplane to escape from prison.

Episode 32 - Gem Robbery

Episode 33 - Wounded

Episode 34 - Fake Cop

One member of a three-person holdup team impersonates a Highway Patrol officer in order to deceive robbery victims into thinking that they need not notify the Patrol themselves.

Episode 35 - Double Cross

Episode 36 - Narcotics

Episode 37 - Hired Killer

Episode 38 - Hostage Copter

Episode 39 - Rabies